Journal of Natural Remedies

A. M. Krupanidhi , H. M. Vagdevi , C. S. Shreedhara , V. P. Vaidya , K. S. Muralikrishna

Abstract

Objective: To study the neuropharmacological activities of the ethanolic extract of Dodonaea viscosa seeds. Materials and methods: Neuropharmacological activities includes behavioural assessment, pentobarbitone-induced sleeping time, motor coordination activity and locomotor activity of the Dodonaea viscosa seeds ethanolic extract was evaluated at the dose of 30 mg/kg and 20 mg/kg (p.o.) respectively. Results: Ethanolic extract of Dodonaea viscosa seeds potentiated phenobarbitone - induced sleeping time, reduced locomotion and the same extract did not induce motor in coordination at dose levels of 30 mg/kg and 20 mg/kg (p.o.). Conclusion: The results of present study have revealed that the ethanolic extract of Dodonaea vsiscosa showed excellent neuropharmacological activities and there is a scope for further envisage.

Keywords

Dodonaea viscosa Seeds, Ethanolic Extract, Hypnosis, Rotarod, Actophotometer

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C. S. Shreedhara , H. N. Aswatha Ram , Sachin B. Zanwar , Gajera P. Falguni

Abstract

Aqueous extract of Argyreia nervosa, which is widely used in the indigenous system of medicine, was studied for its in vitro scavenging activity by different methods viz. DPPH radical scavenging, ABTS radical scavenging, lipid peroxidation, iron chelating activity, superoxide scavenging, total antioxidant capacity, Nitric oxide scavenging and Non-enzymatic Glycosylation of Haemoglobin assay. The results were analyzed statistically by regression method. Its antioxidant activity was estimated by IC₅₀ value and the values are 88.86 μg/ml for DPPH radical scavenging, 66.64 μg/ml for ABTS radical scavenging, 31.57 μg/ml for lipid peroxidation, 8.0 μg/ml for iron chelating activity, 113.20 μg/ml for Nitric oxide scavenging and 7.51 μg/ml for superoxide scavenging. Total antioxidant capacity was found to be 22.0 μg/ml. In Haemoglobin glycosylation the % scavenging was found to be 43.77% and 64.42% for concentration 0.5 mg/ml and 1.0 mg/ml respectively. In all the methods, the extract showed its ability to scavenge free radicals in a concentration dependent manner. The results indicate that Argyreia nervosa has significant antioxidant activity.

Keywords

Argyreia Nervosa, ABTS, Haemoglobin Glycosylation, Superoxide Scavenging, Lipid Peroxidation

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